RAF Typhoon jets have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syria operated by the IS group, per a report from the UK's MoD.
The site, located using reconnaissance, was believed to be housing weapons and explosive materials, the release indicated, and was positioned in mountains just to the north of the historic site of Palmyra in central Syria.
"The RAF jets employed precision-guided Paveway IV munitions to strike a number of entry passages providing entry to the depot... early reports suggest the target was engaged successfully," the ministry announced.
There was no indication of any civilian casualties in the strike conducted Saturday night and every plane involved returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - imposed militant control over large swathes of Syria and Iraq until 2019.
"This strike underscores British leadership, and commitment to operate in unison with our allies, to stamp out any revival of the terrorist group and their harmful and extremist ideologies in the area," Britain's Defence Chief John Healey stated.
UK warplanes have performed overwatch operations over Syrian airspace to "forestall any efforts to regroup" of Islamic State subsequent to its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to every member of our armed forces who took part in this operation for their skill and their bravery," he added. "They were part of a great many UK service members stationed over the festive period. This mission, to eliminate militants who threaten our security, highlights how UK forces are ready to step up, all year round, protecting the UK at home and influential overseas."
In December, the US military executed what it termed a "massive strike" targeting Daesh sites in Syria, after an attack resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The U.N. says Daesh still boasts roughly 5-7 thousand combatants in Iraq and Syria.